Men Taking Dutasteride Received Better Diagnosis Of PSA Tests

December 26, 2010

So many times you would leave the urologist’s office, after having the results of a PSA test explained, filled with much uncertainty as to whether the indicators could be incorrect. Knowing that PSA screening is not a precise diagnostic instrument for determining cancer of the prostate, can lead to anxiety and depression. But those days are almost over. New research study found PSA screening is more reliable in men taking the PSA level reduction drug dutasteride.

Dutasteride is a dual 5-alpha-reductase inhibitor, approved by the FDA for the treatment of symptomatic benign prostatic hyperplasia (BPH), better known as enlarged prostate.

A hormone, dihydrotestosterone (DHT), causes the prostate to slowly grow over time. Dutasteride slows down the production of DHT over time, leading to shrinkage of the enlarged prostate, and reducing the symptoms of BPH.

Dutasteride reduces the risk of prostate cancers by keeping the turmors small enough to avoid detection by a biopsy. Thus, men taking Dutasteride who still show a subsequent rise in PSA levels should be associated with having aggressive high-grade cancer.

This new study reveals how Dutasteride enhances the ability of rising PSA levels to detect high-grade cancers that require early diagnosis and treatment, while decreasing the detection of tumors that are harmless. However, it doesn’t mean men should take dutasteride to better PSA scores.



Second Prostate Biopsy

October 31, 2010

The good news you just received about the result of a second prostate biopsy test could be misleading. Pathologists estimates show 20 percent of all prostate biopsies are false negative… meaning they can miss cancer.

A negative biopsy doesn’t mean you don’t have cancer. Your chances of having cancer increases, if your biopsy only included samples from part of your prostate. In fact the cancer could be quite extensive. The greater the number of samples biopsied, the better your chances of being misdiagnosed.

Perhaps there was no need to do the test at that time. Because, according to Dr. James A. Eastham at Memorial Sloan-Kettering Center, no one should be referred for a biopsy based on one single PSA test that is slightly elevated. Did you have a second prostate-specific antigen (PSA) before the second prostate biopsy was performed?

You should be here at this threshold because your second prostate-specific antigen (PSA), and digital rectal exam (DRE) continued to be abnormal. Experts recommend repeating the test 4 to 6 weeks before doing second biopsy. False positives are common, because cancer is not the only cause for increased PSA levels. A recent episode with constipation, inflammation, or recent ejaculation can raise your PSA score. But fluctuations should never be taken lightly.

Researchers at Oregon Health & Science University Cancer Institute and Portland Veterans Medical Center have discovered a way to identify which men need second prostate biopsy, even though they were given a clean bill of health after the first biopsy. The single most definite indicator given for a repeat biopsy was a high PSA, Gleason score 7 or higher, adjusted for prostate size.

Prostate cancer is the second most deadliest cancer in men. An estimated 300,000 are diagnosed annually, and 30,000 men will die of the disease, according to the American Cancer Society. You could be one of them.


Once-Daily Tadalafil May Improve Signs and Symptoms of BPH

July 26, 2009

There is enough data available to support once-a-day use of tadalafil in men with erectile dysfunction, and signs and symptoms of BPH. This is the finding, reported by UroToday, of a recent study on the effects of tadalafil on benign prostatitic hyperplasia.

The study included sexually active men with ED, who also suffered BPH and lower urinary tract symptoms, such as intermittency, urgency, incomplete emptying, weak urinary stream, urinary frequency, straining and nocturia.

The result of the study showed significant improvements from baseline with once-daily tadalafil in all stratifications. Hereby suggesting that once-daily tadalafil may be effective in treating a diversified group of men suffering from BPH and other lower urinary tract symptoms.


Dutasteride Study Shows Reduced Prostate Cancer Risk

May 3, 2009

Long term study shows Dutasteride reduced the risk of prostate cancer detected via prostate biopsy by 23% over a period of four years. The study group included men between the age of 50 to 75 who had increased cancer risk, with prostate specific antigen (PSA) levels between 2.5 and 10 ng/ml.

Dutasteride is a 5-alpha-reductase enzyme inhibitor that inhibits both type 1 and type 2 isoenzymes. These enzymes convert testosterone into dihydrotestosterone (DHT) in the prostate gland. High levels of dihydrotestosterone accumulates and cause hyperplasia. Dutasteride capsules have been approved by the FDA for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland.

BPH is benign enlargement of the prostate gland in men over forty, which may not present any problems until over sixty. BPH causes urinary track symptoms such as frequent urination, leaking, and urinary urgency. Dutasteride trials show significant improvement of urinary track symptoms.


Patients Choose To Do Little About Prostate Cancer

December 21, 2008

Thirty percent of patients who are diagnosed with prostate cancer choose the wait-and-see option, also called ‘active surveillance’, which is unique only to prostate cancer, and cannot be applied to other type of cancers, since prostate cancer is a very slow growing neoplasm. Those men who chose this option, must still have regular PSA testing and physical testing every 6 month, plus a second biopsy after a year. In doing so men may avoid impotence, incontinence and other side effects. The no treatment option is only possible because doctors have the data to support it. It doesn’t mean no treatment ever, but rather no treatment right now.


Negative Prostate Biopsy

January 1, 2007

At this moment you’re feeling quite relieve. The verdict is in, and the pathologists delivered a ruling of ‘no cancer’. But whatever is contributing to elevated prostate specific antigen (PSA) level, may not cause prostate cancer. Now it’s your job to make sure that it doesn’t.

Prostate cancer is cause by two conditions that effect normal functioning of the prostate gland.

  • Benign prostate hyperplasia or BPH.
  • Inflammation or infection of the prostate, or prostatitis.

Either of these conditions cause elevated prostate specific antigen level, which led your urologist to suspect you may have prostate cancer.

BPH is treated with drugs. If there is a bacterial infection in the prostate, this can also be treated with drugs. The urologist will monitor your prostate health with digital rectal exams, and PSA tests.

Your job is to maintain overall excellent health to reduce the risk of prostate cancer. There may be other factors beyond your control, which may increase the risk. But if you follow these simple guidelines, you may help reduce the risk.

  • A balanced low-fat diet. Eat lots of fruits and vegetables containing lycopene – tomatoes, grapefruits, watermelons.
  • Reduce physical and mental stress. Sleep for 8 hours every night. Exercise regularly, and adopt only those activities that induce relaxation.
  • Reduce alcohol consumption, and quit smoking.
  • Report any changes, no matter how insignificant, to your doctor.
  • Never miss any scheduled follow-up exams.

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